The assumption of using a static graph to represent multivariate time-varying signals oversimplifies the complexity of modeling their interactions over time. We propose a Dynamic Multi-hop model that captures dynamic interactions among time-varying node signals, while also accounting for time-varying edge signals, by extracting latent edges through topological diffusion and edge pruning. The resulting graphs are time-varying and sparse, capturing key dynamic node interactions and representing signal diffusion to both near and distant neighbors over time. The Dynamic Multi-hop Estimation algorithm is further proposed, accurately representing the interaction dynamics among node signals while enabling adaptive estimation of time-varying multivariate signals spatially and temporally. The Dynamic Multi-hop Estimation is evaluated under two real-world datasets of brain network and stock market for the online estimation of partially observed time-varying signals corrupted by noise.