Spectroscopic measurements can show distorted spectra shapes arising from a mixture of absorbing and scattering contributions. These distortions (or baselines) often manifest themselves as non-constant offsets or low-frequency oscillations. As a result, these baselines can adversely affect analytical and quantitative results. Baseline correction is an umbrella term where one applies pre-processing methods to obtain baseline spectra (the unwanted distortions) and then remove the distortions by differencing. However, current state-of-the art baseline correction methods do not utilize analyte concentrations even if they are available, or even if they contribute significantly to the observed spectral variability. We examine a class of state-of-the-art methods (penalized baseline correction) and modify them such that they can accommodate a priori analyte concentration such that prediction can be enhanced. Performance will be access on two near infra-red data sets across both classical penalized baseline correction methods (without analyte information) and modified penalized baseline correction methods (leveraging analyte information).