The paper introduces a Signed Generalized Random Dot Product Graph (SGRDPG) model, which is a variant of the Generalized Random Dot Product Graph (GRDPG), where, in addition, edges can be positive or negative. The setting is extended to a multiplex version, where all layers have the same collection of nodes and follow the SGRDPG. The only common feature of the layers of the network is that they can be partitioned into groups with common subspace structures, while otherwise all matrices of connection probabilities can be all different. The setting above is extremely flexible and includes a variety of existing multiplex network models as its particular cases. The paper fulfills two objectives. First, it shows that keeping signs of the edges in the process of network construction leads to a better precision of estimation and clustering and, hence, is beneficial for tackling real world problems such as analysis of brain networks. Second, by employing novel algorithms, our paper ensures equivalent or superior accuracy than has been achieved in simpler multiplex network models. In addition to theoretical guarantees, both of those features are demonstrated using numerical simulations and a real data example.