Image structure-texture decomposition is a long-standing and fundamental problem in both image processing and computer vision fields. In this paper, we propose a generalized semi-sparse regularization framework for image structural analysis and extraction, which allows us to decouple the underlying image structures from complicated textural backgrounds. Combining with different textural analysis models, such a regularization receives favorable properties differing from many traditional methods. We demonstrate that it is not only capable of preserving image structures without introducing notorious staircase artifacts in polynomial-smoothing surfaces but is also applicable for decomposing image textures with strong oscillatory patterns. Moreover, we also introduce an efficient numerical solution based on an alternating direction method of multipliers (ADMM) algorithm, which gives rise to a simple and maneuverable way for image structure-texture decomposition. The versatility of the proposed method is finally verified by a series of experimental results with the capability of producing comparable or superior image decomposition results against cutting-edge methods.