Safe AI -- How is this Possible?

Ttraditional safety engineering is coming to a turning point moving from deterministic, non-evolving systems operating in well-defined contexts to increasingly autonomous and learning-enabled AI systems which are acting in largely unpredictable operating contexts. We outline some of underlying challenges of safe AI and suggest a rigorous engineering framework for minimizing uncertainty, thereby increasing confidence, up to tolerable levels, in the safe behavior of AI systems.