The Dark Energy Survey is able to collect image data of an extremely large number of extragalactic objects, and it can be reasonably assumed that many unusual objects of high scientific interest are hidden inside these data. Due to the extreme size of DES data, identifying these objects among many millions of other celestial objects is a challenging task. The problem of outlier detection is further magnified by the presence of noisy or saturated images. When the number of tested objects is extremely high, even a small rate of noise or false positives leads to a very large number of false detections, making an automatic system impractical. This study applies an automatic method for automatic detection of outlier objects in the first data release of the Dark Energy Survey. By using machine learning-based outlier detection, the algorithm is able to identify objects that are visually different from the majority of the other objects in the database. An important feature of the algorithm is that it allows to control the false-positive rate, and therefore can be used for practical outlier detection. The algorithm does not provide perfect accuracy in the detection of outlier objects, but it reduces the data substantially to allow practical outlier detection. For instance, the selection of the top 250 objects after applying the algorithm to more than $2\cdot10^6$ DES images provides a collection of uncommon galaxies. Such collection would have been extremely time-consuming to compile by using manual inspection of the data.