Fr\'echet regression is becoming a mainstay in modern data analysis for analyzing non-traditional data types belonging to general metric spaces. This novel regression method utilizes the pairwise distances between the random objects, which makes the choice of metric crucial in the estimation. In this paper, the effect of metric choice on the estimation of the dimension reduction subspace for the regression between random responses and Euclidean predictors is investigated. Extensive numerical studies illustrate how different metrics affect the central and central mean space estimates for regression involving responses belonging to some popular metric spaces versus Euclidean predictors. An analysis of the distributions of glycaemia based on continuous glucose monitoring data demonstrate how metric choice can influence findings in real applications.