This report discusses the application of neural networks (NNs) as small segments of the brain. The networks representing the biological connectome are altered both spatially and temporally. The degradation techniques applied here are "weight degradation", "weight scrambling", and variable activation function. These methods aim to shine light on the study of neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's disease as well as strokes and brain tumors disrupting the flow of information in the brain's network. Fundamental insights to memory loss and generalized learning dysfunction are gained by monitoring the network's error function during network degradation. The biological significance of each facet is also discussed.