This paper deals with modeling, analysis, and optimization of power amplifiers (PAs) placed in a cascaded structure, particularly the effect of cascaded nonlinearities is studied by showing potential ways to minimize the total nonlinearities. The nonlinear least-squares algorithm is proposed to optimize the PA parameters along with the input power level, and thereby minimize the total nonlinearities in the cascaded structure. The simulation results demonstrate that the performance of the optimized configurations for up to five PAs using the proposed framework can improve the linearity properties of the overall cascade.