Deep neural network (DNN)-based adaptive controllers can be used to compensate for unstructured uncertainties in nonlinear dynamic systems. However, DNNs are also very susceptible to overfitting and co-adaptation. Dropout regularization is an approach where nodes are randomly dropped during training to alleviate issues such as overfitting and co-adaptation. In this paper, a dropout DNN-based adaptive controller is developed. The developed dropout technique allows the deactivation of weights that are stochastically selected for each individual layer within the DNN. Simultaneously, a Lyapunov-based real-time weight adaptation law is introduced to update the weights of all layers of the DNN for online unsupervised learning. A non-smooth Lyapunov-based stability analysis is performed to ensure asymptotic convergence of the tracking error. Simulation results of the developed dropout DNN-based adaptive controller indicate a 38.32% improvement in the tracking error, a 53.67% improvement in the function approximation error, and 50.44% lower control effort when compared to a baseline adaptive DNN-based controller without dropout regularization.