Medical imaging informatics is a rapidly growing field that combines the principles of medical imaging and informatics to improve the acquisition, management, and interpretation of medical images. This chapter introduces the basic concepts of medical imaging informatics, including image processing, feature engineering, and machine learning. It also discusses the recent advancements in computer vision and deep learning technologies and how they are used to develop new quantitative image markers and prediction models for disease detection, diagnosis, and prognosis prediction. By covering the basic knowledge of medical imaging informatics, this chapter provides a foundation for understanding the role of informatics in medicine and its potential impact on patient care.