Flood simulation and forecast capability have been greatly improved thanks to advances in data assimilation (DA) strategies incorporating various types of observations; many are derived from spatial Earth Observation. This paper focuses on the assimilation of 2D flood observations derived from Synthetic Aperture Radar (SAR) images acquired during a flood event with a dual state-parameter Ensemble Kalman Filter (EnKF). Binary wet/dry maps are here expressed in terms of wet surface ratios (WSR) over a number of subdomains of the floodplain. This ratio is further assimilated jointly with in-situ water-level observations to improve the flow dynamics within the floodplain. However, the non-Gaussianity of the observation errors associated with SAR-derived measurements break a major hypothesis for the application of the EnKF, thus jeopardizing the optimality of the filter analysis. The novelty of this paper lies in the treatment of the non-Gaussianity of the SAR-derived WSR observations with a Gaussian anamorphosis process (GA). This DA strategy was validated and applied over the Garonne Marmandaise catchment (South-west of France) represented with the TELEMAC-2D hydrodynamic model, first in a twin experiment and then for a major flood event that occurred in January-February 2021. It was shown that assimilating SAR-derived WSR observations, in complement to the in-situ water-level observations significantly improves the representation of the flood dynamics. Also, the GA transformation brings further improvement to the DA analysis, while not being a critical component in the DA strategy. This study heralds a reliable solution for flood forecasting over poorly gauged catchments thanks to available remote-sensing datasets.