Recently, the diffusion model with the training-free methods has succeeded in conditional image generation tasks. However, there is an efficiency problem because it requires calculating the gradient with high computational cost, and previous methods make strong assumptions to solve it, sacrificing generalization. In this work, we propose the Fisher information guided diffusion model (FIGD). Concretely, we introduce the Fisher information to estimate the gradient without making any additional assumptions to reduce computation cost. Meanwhile, we demonstrate that the Fisher information ensures the generalization of FIGD and provides new insights for training-free methods based on the information theory. The experimental results demonstrate that FIGD could achieve different conditional generations more quickly while maintaining high quality.