Auxetic structures, known for their negative Poisson's ratio, exhibit effective elastic properties heavily influenced by their underlying structural geometry and base material properties. While periodic homogenization of auxetic unit cells can be used to investigate these properties, it is computationally expensive and limits design space exploration and inverse analysis. In this paper, surrogate models are developed for the real-time prediction of the effective elastic properties of auxetic unit cells with orthogonal voids of different shapes. The unit cells feature orthogonal voids in four distinct shapes, including rectangular, diamond, oval, and peanut-shaped voids, each characterized by specific void diameters. The generated surrogate models accept geometric parameters and the elastic properties of the base material as inputs to predict the effective elastic constants in real-time. This rapid evaluation enables a practical inverse analysis framework for obtaining the optimal design parameters that yield the desired effective response. The fast Fourier transform (FFT)-based homogenization approach is adopted to efficiently generate data for developing the surrogate models, bypassing concerns about periodic mesh generation and boundary conditions typically associated with the finite element method (FEM). The performance of the generated surrogate models is rigorously examined through a train/test split methodology, a parametric study, and an inverse problem. Finally, a graphical user interface (GUI) is developed, offering real-time prediction of the effective tangent stiffness and performing inverse analysis to determine optimal geometric parameters.