The increasing volume of papers and proposals undergoing peer review emphasizes the pressing need for greater automation to effectively manage the growing scale. In this study, we present the deployment and evaluation of machine learning and optimization techniques for assigning proposals to reviewers that was developed for the Atacama Large Millimeter/submillimeter Array (ALMA) during the Cycle 10 Call for Proposals issued in 2023. By utilizing topic modeling algorithms, we identify the proposal topics and assess reviewers' expertise based on their historical ALMA proposal submissions. We then apply an adapted version of the assignment optimization algorithm from PeerReview4All (Stelmakh et al. 2021a) to maximize the alignment between proposal topics and reviewer expertise. Our evaluation shows a significant improvement in matching reviewer expertise: the median similarity score between the proposal topic and reviewer expertise increased by 51 percentage points compared to the previous cycle, and the percentage of reviewers reporting expertise in their assigned proposals rose by 20 percentage points. Furthermore, the assignment process proved highly effective in that no proposals required reassignment due to significant mismatches, resulting in a savings of 3 to 5 days of manual effort.