The Semantic Web is becoming more and more a reality, as the required technologies have reached an appropriate level of maturity. However, at this stage, it is important to provide tools facilitating the use and deployment of these technologies by end-users. In this paper, we describe EdHibou, an automatically generated, ontology-based graphical user interface that integrates in a semantic portal. The particularity of EdHibou is that it makes use of OWL reasoning capabilities to provide intelligent features, such as decision support, upon the underlying ontology. We present an application of EdHibou to medical decision support based on a formalization of clinical guidelines in OWL and show how it can be customized thanks to an ontology of graphical components.