With advanced data analytical techniques, efforts for more accurate decision support systems for disease prediction are on rise. Surveys by World Health Organization (WHO) indicate a great increase in number of diabetic patients and related deaths each year. Early diagnosis of diabetes is a major concern among researchers and practitioners. The paper presents an application of \textit{Automatic Multilayer Perceptron }which\textit{ }is combined with an outlier detection method \textit{Enhanced Class Outlier Detection using distance based algorithm }to create a prediction framework named as Enhanced Class Outlier with Automatic Multi layer Perceptron (ECO-AMLP). A series of experiments are performed on publicly available Pima Indian Diabetes Dataset to compare ECO-AMLP with other individual classifiers as well as ensemble based methods. The outlier technique used in our framework gave better results as compared to other pre-processing and classification techniques. Finally, the results are compared with other state-of-the-art methods reported in literature for diabetes prediction on PIDD and achieved accuracy of 88.7\% bests all other reported studies.