We investigate the task of building a domain aware chat system which generates intelligent responses in a conversation comprising of different domains. The domain, in this case, is the topic or theme of the conversation. To achieve this, we present DOM-Seq2Seq, a domain aware neural network model based on the novel technique of using domain-targeted sequence-to-sequence models (Sutskever et al., 2014) and a domain classifier. The model captures features from current utterance and domains of the previous utterances to facilitate the formation of relevant responses. We evaluate our model on automatic metrics and compare our performance with the Seq2Seq model.