The trend of massive connectivity pushes forward the explosive growth of end devices. The emergence of various applications has prompted a demand for pervasive connectivity and more efficient computing paradigms. On the other hand, the lack of computational capacity of the end devices restricts the implementation of the intelligent applications, and becomes a bottleneck of the multiple access for supporting massive connectivity. Mobile cloud computing (MCC) and mobile edge computing (MEC) techniques enable end devices to offload local computation-intensive tasks to servers by networks. In this paper, we consider the cloud-edge-end collaborative networks to utilize distributed computing resources. Furthermore, we apply task-oriented semantic communications to tackle the fast-varying channel between the end devices and MEC servers and reduce the communication cost. To minimize long-term energy consumption on constraints queue stability and computational delay, a Lyapunov-guided deep reinforcement learning hybrid (DRLH) framework is proposed to solve the mixed integer non-linear programming (MINLP) problem. The long-term energy consumption minimization problem is transformed into the deterministic problem in each time frame. The DRLH framework integrates a model-free deep reinforcement learning algorithm with a model-based mathematical optimization algorithm to mitigate computational complexity and leverage the scenario information, so that improving the convergence performance. Numerical results demonstrate that the proposed DRLH framework achieves near-optimal performance on energy consumption while stabilizing all queues.