The complexity of cultures in the modern world is now beyond human comprehension. Cognitive sciences cast doubts on the traditional explanations based on mental models. The core subjects in humanities may lose their importance. Humanities have to adapt to the digital age. New, interdisciplinary branches of humanities emerge. Instant access to information will be replaced by instant access to knowledge. Understanding the cognitive limitations of humans and the opportunities opened by the development of artificial intelligence and interdisciplinary research necessary to address global challenges is the key to the revitalization of humanities. Artificial intelligence will radically change humanities, from art to political sciences and philosophy, making these disciplines attractive to students and enabling them to go beyond current limitations.