Indoor positioning applications are craving for ever higher precision and accuracy across the entire coverage zone. Optimal anchor placement and the deployment of multiple distributed anchor nodes could have a major impact in this regard. This paper examines the influences of these two difficult to approach hypotheses by means of a straightforward ultrasonic 3D indoor positioning system deployed in a real-life scenario via a geometric based simulation framework. To obtain an optimal anchor placement, a particle swarm optimization (PSO) algorithm is introduced and consequently performed for setups ranging from 4 to 10 anchors. In this way, besides the optimal anchor placement layout, the influence of deploying several distributed anchor nodes is investigated. In order to theoretically compare the optimization progress, a system model and Cram\'er-Rao lower bound (CRLB) are established and the results are quantified based on the simulation data. With limited anchors, the placement is crucial to obtain a high precision high reliability (HPHR) indoor positioning system (IPS), while the addition of anchors, to a lesser extent, gives a supplementary improvement.