Due to the influence of imaging equipment and complex imaging environments, most images in daily life have features of intensity inhomogeneity and noise. Therefore, many scholars have designed many image segmentation algorithms to address these issues. Among them, the active contour model is one of the most effective image segmentation algorithms.This paper proposes an active contour model driven by the hybrid signed pressure function that combines global and local information construction. Firstly, a new global region-based signed pressure function is introduced by combining the average intensity of the inner and outer regions of the curve with the median intensity of the inner region of the evolution curve. Then, the paper uses the energy differences between the inner and outer regions of the curve in the local region to design the signed pressure function of the local term. Combine the two SPF function to obtain a new signed pressure function and get the evolution equation of the new model. Finally, experiments and numerical analysis show that the model has excellent segmentation performance for both intensity inhomogeneous images and noisy images.