This paper presents for the first time successful results of active flow control with multiple independently controlled zero-net-mass-flux synthetic jets. The jets are placed on a three-dimensional cylinder along its span with the aim of reducing the drag coefficient. The method is based on a deep-reinforcement-learning framework that couples a computational-fluid-dynamics solver with an agent using the proximal-policy-optimization algorithm. We implement a multi-agent reinforcement-learning framework which offers numerous advantages: it exploits local invariants, makes the control adaptable to different geometries, facilitates transfer learning and cross-application of agents and results in significant training speedup. In this contribution we report significant drag reduction after applying the DRL-based control in three different configurations of the problem.