Objective: The aim of this study was to build an effective co-reference resolution system tailored for the biomedical domain. Materials and Methods: Experiment materials used in this study is provided by the 2011 i2b2 Natural Language Processing Challenge. The 2011 i2b2 challenge involves coreference resolution in medical documents. Concept mentions have been annotated in clinical texts, and the mentions that co-refer in each document are to be linked by coreference chains. Normally, there are two ways of constructing a system to automatically discover co-referent links. One is to manually build rules for co-reference resolution, and the other category of approaches is to use machine learning systems to learn automatically from training datasets and then perform the resolution task on testing datasets. Results: Experiments show the existing co-reference resolution systems are able to find some of the co-referent links, and our rule based system performs well finding the majority of the co-referent links. Our system achieved 89.6% overall performance on multiple medical datasets. Conclusion: The experiment results show that manually crafted rules based on observation of training data is a valid way to accomplish high performance in this coreference resolution task for the critical biomedical domain.