Real-Time Phase Contrast MRI to quantify Cerebral arterial flow change during variations breathing

Cerebral arterial blood flow (CABF) can be investigated in few seconds without any synchronization by Real-Time phase contrast. Significant changes in CABF were found between expiration and inspiration during normal breathing of healthy volunteers. Synopsis (100/100) Real-time phase contrast MRI has been applied to investigate cerebral arterial blood flow (CABF) during normal breathing of healthy volunteers. We developed a novel time-domain analysis method to quantify the effect of normal breathing on several parameters of CABF. We found the existence of a delay between the recorded respiratory signal from the belt sensor and the breathing frequency component present in the reconstructed arterial blood flows. During the expiratory, the mean flow rate of CABF increased by 4.4$\pm$1.7%, stroke volume of CABF increased by 9.8$\pm$3.1% and the duration of the cardiac period of CABF increased by 8.1$\pm$3%.

Flow 2.0 -a flexible, scalable, cross-platform post-processing software for realtime phase contrast sequences

Flow 2.0 is an end-to-end easy-of-use software that allows us to quickly, robustly and accurately perform a batch process real-time phase contrast data and multivariate analysis of the effect of respiration on cerebral fluids circulation. Synopsis (99/100) Real-time phase contrast sequences (RT-PC) have potential value as a scientific and clinical tool in quantifying the effects of respiration on cerebral circulation. To simplify its complicated post-processing process, we developed Flow 2.0 software, which provides a complete post-processing workflow including converting DICOM data, image segmentation, image processing, data extraction, background field correction, antialiasing filter, signal processing and analysis and a novel time-domain method for quantifying the effect of respiration on the cerebral circulation. This end-to-end software allows us to quickly, robustly and accurately perform batch process RT-PC and multivariate analysis of the effects of respiration on cerebral circulation.