Abstract:The latest cancer statistics indicate a decrease in cancer-related mortality. However, due to the growing and ageing population, the absolute number of people living with cancer is set to keep increasing. This paper presents ASCAPE, an open AI infrastructure that takes advantage of the recent advances in Artificial Intelligence (AI) and Machine Learning (ML) to support cancer patients quality of life (QoL). With ASCAPE health stakeholders (e.g. hospitals) can locally process their private medical data and then share the produced knowledge (ML models) through the open AI infrastructure.