LIT-GRAPH: Evaluating Deep vs. Shallow Graph Embeddings for High-Quality Text Recommendation in Domain-Specific Knowledge Graphs

This study presents LIT-GRAPH (Literature Graph for Recommendation and Pedagogical Heuristics), a novel knowledge graph-based recommendation system designed to scaffold high school English teachers in selecting diverse, pedagogically aligned instructional literature. The system is built upon an ontology for English literature, addressing the challenge of curriculum stagnation, where we compare four graph embedding paradigms: DeepWalk, Biased Random Walk (BRW), Hybrid (concatenated DeepWalk and BRW vectors), and the deep model Relational Graph Convolutional Network (R-GCN). Results reveal a critical divergence: while shallow models excelled in structural link prediction, R-GCN dominated semantic ranking. By leveraging relation-specific message passing, the deep model prioritizes pedagogical relevance over raw connectivity, resulting in superior, high-quality, domain-specific recommendations.

Utilizing AI and Social Media Analytics to Discover Adverse Side Effects of GLP-1 Receptor Agonists

Adverse side effects (ASEs) of drugs, revealed after FDA approval, pose a threat to patient safety. To promptly detect overlooked ASEs, we developed a digital health methodology capable of analyzing massive public data from social media, published clinical research, manufacturers' reports, and ChatGPT. We uncovered ASEs associated with the glucagon-like peptide 1 receptor agonists (GLP-1 RA), a market expected to grow exponentially to $133.5 billion USD by 2030. Using a Named Entity Recognition (NER) model, our method successfully detected 21 potential ASEs overlooked upon FDA approval, including irritability and numbness. Our data-analytic approach revolutionizes the detection of unreported ASEs associated with newly deployed drugs, leveraging cutting-edge AI-driven social media analytics. It can increase the safety of new drugs in the marketplace by unlocking the power of social media to support regulators and manufacturers in the rapid discovery of hidden ASE risks.