Representation Learning with Semantic-aware Instance and Sparse Token Alignments

Medical contrastive vision-language pre-training (VLP) has demonstrated significant potential in improving performance on downstream tasks. Traditional approaches typically employ contrastive learning, treating paired image-report samples as positives and unpaired ones as negatives. However, in medical datasets, there can be substantial similarities between images or reports from different patients. Rigidly treating all unpaired samples as negatives, can disrupt the underlying semantic structure and negatively impact the quality of the learned representations. In this paper, we propose a multi-level alignment framework, Representation Learning with Semantic-aware Instance and Sparse Token Alignments (SISTA) by exploiting the semantic correspondence between medical image and radiology reports at two levels, i.e., image-report and patch-word levels. Specifically, we improve the conventional contrastive learning by incorporating inter-report similarity to eliminate the false negatives and introduce a method to effectively align image patches with relevant word tokens. Experimental results demonstrate the effectiveness of the proposed framework in improving transfer performance across different datasets on three downstream tasks: image classification, image segmentation, and object detection. Notably, our framework achieves significant improvements in fine-grained tasks even with limited labeled data. Codes and pre-trained models will be made available.

Multi-scale Feature Enhancement in Multi-task Learning for Medical Image Analysis

Traditional deep learning methods in medical imaging often focus solely on segmentation or classification, limiting their ability to leverage shared information. Multi-task learning (MTL) addresses this by combining both tasks through shared representations but often struggles to balance local spatial features for segmentation and global semantic features for classification, leading to suboptimal performance. In this paper, we propose a simple yet effective UNet-based MTL model, where features extracted by the encoder are used to predict classification labels, while the decoder produces the segmentation mask. The model introduces an advanced encoder incorporating a novel ResFormer block that integrates local context from convolutional feature extraction with long-range dependencies modeled by the Transformer. This design captures broader contextual relationships and fine-grained details, improving classification and segmentation accuracy. To enhance classification performance, multi-scale features from different encoder levels are combined to leverage the hierarchical representation of the input image. For segmentation, the features passed to the decoder via skip connections are refined using a novel dilated feature enhancement (DFE) module, which captures information at different scales through three parallel convolution branches with varying dilation rates. This allows the decoder to detect lesions of varying sizes with greater accuracy. Experimental results across multiple medical datasets confirm the superior performance of our model in both segmentation and classification tasks, compared to state-of-the-art single-task and multi-task learning methods.

Cross Feature Fusion of Fundus Image and Generated Lesion Map for Referable Diabetic Retinopathy Classification

Diabetic Retinopathy (DR) is a primary cause of blindness, necessitating early detection and diagnosis. This paper focuses on referable DR classification to enhance the applicability of the proposed method in clinical practice. We develop an advanced cross-learning DR classification method leveraging transfer learning and cross-attention mechanisms. The proposed method employs the Swin U-Net architecture to segment lesion maps from DR fundus images. The Swin U-Net segmentation model, enriched with DR lesion insights, is transferred to generate a lesion map. Both the fundus image and its segmented lesion map are used as complementary inputs for the classification model. A cross-attention mechanism is deployed to improve the model's ability to capture fine-grained details from the input pairs. Our experiments, utilizing two public datasets, FGADR and EyePACS, demonstrate a superior accuracy of 94.6%, surpassing current state-of-the-art methods by 4.4%. To this end, we aim for the proposed method to be seamlessly integrated into clinical workflows, enhancing accuracy and efficiency in identifying referable DR.