Sam2Rad: A Segmentation Model for Medical Images with Learnable Prompts

Foundation models like the segment anything model require high-quality manual prompts for medical image segmentation, which is time-consuming and requires expertise. SAM and its variants often fail to segment structures in ultrasound (US) images due to domain shift. We propose Sam2Rad, a prompt learning approach to adapt SAM and its variants for US bone segmentation without human prompts. It introduces a prompt predictor network (PPN) with a cross-attention module to predict prompt embeddings from image encoder features. PPN outputs bounding box and mask prompts, and 256-dimensional embeddings for regions of interest. The framework allows optional manual prompting and can be trained end-to-end using parameter-efficient fine-tuning (PEFT). Sam2Rad was tested on 3 musculoskeletal US datasets: wrist (3822 images), rotator cuff (1605 images), and hip (4849 images). It improved performance across all datasets without manual prompts, increasing Dice scores by 2-7% for hip/wrist and up to 33% for shoulder data. Sam2Rad can be trained with as few as 10 labeled images and is compatible with any SAM architecture for automatic segmentation.

Deep Metric Learning-Based Out-of-Distribution Detection with Synthetic Outlier Exposure

In this paper, we present a novel approach that combines deep metric learning and synthetic data generation using diffusion models for out-of-distribution (OOD) detection. One popular approach for OOD detection is outlier exposure, where models are trained using a mixture of in-distribution (ID) samples and ``seen" OOD samples. For the OOD samples, the model is trained to minimize the KL divergence between the output probability and the uniform distribution while correctly classifying the in-distribution (ID) data. In this paper, we propose a label-mixup approach to generate synthetic OOD data using Denoising Diffusion Probabilistic Models (DDPMs). Additionally, we explore recent advancements in metric learning to train our models. In the experiments, we found that metric learning-based loss functions perform better than the softmax. Furthermore, the baseline models (including softmax, and metric learning) show a significant improvement when trained with the generated OOD data. Our approach outperforms strong baselines in conventional OOD detection metrics.