This contribution summarizes the participation of the UNIMIB team to the TREC 2021 Clinical Trials Track. We have investigated the effect of different query representations combined with several retrieval models on the retrieval performance. First, we have implemented a neural re-ranking approach to study the effectiveness of dense text representations. Additionally, we have investigated the effectiveness of a novel decision-theoretic model for relevance estimation. Finally, both of the above relevance models have been compared with standard retrieval approaches. In particular, we combined a keyword extraction method with a standard retrieval process based on the BM25 model and a decision-theoretic relevance model that exploits the characteristics of this particular search task. The obtained results show that the proposed keyword extraction method improves 84% of the queries over the TREC's median NDCG@10 measure when combined with either traditional or decision-theoretic relevance models. Moreover, regarding RPEC@10, the employed decision-theoretic model improves 85% of the queries over the reported TREC's median value.