This article introduces a cost-effective gateway into the fascinating world of neuroscience: the PIEEG-16, a versatile shield for RaspberryPi designed to measure 16 channels of various biosignals, including EEG (electroencephalography), EMG (electromyography), and ECG (electrocardiography) without any data transfer over the network (Wi-Fi, Bluetooth) and processing and feature ectraction directly on the Raspberry in real-time. This innovative tool opens up new possibilities for neuroscience research and brain-computer interface experiments. By combining the power of RaspberryPi with specialized biosignal measurement capabilities, the PIEEG-16 represents a significant step forward in democratizing neuroscience research and exploration.