Permutation invariance is among the most common symmetry that can be exploited to simplify complex problems in machine learning (ML). There has been a tremendous surge of research activities in building permutation invariant ML architectures. However, less attention is given to how to statistically test for permutation invariance of variables in a multivariate probability distribution where the dimension is allowed to grow with the sample size. Also, in terms of a statistical theory, little is known about how permutation invariance helps with estimation in reducing dimensions. In this paper, we take a step back and examine these questions in several fundamental problems: (i) testing the assumption of permutation invariance of multivariate distributions; (ii) estimating permutation invariant densities; (iii) analyzing the metric entropy of smooth permutation invariant function classes and compare them with their counterparts without imposing permutation invariance; (iv) kernel ridge regression of permutation invariant functions in reproducing kernel Hilbert space. In particular, our methods for (i) and (iv) are based on a sorting trick and (ii) is based on an averaging trick. These tricks substantially simplify the exploitation of permutation invariance.