In this work, we investigate the effect of fractional Doppler on the performance of a system using orthogonal time frequency space (OTFS) modulation and non-orthogonal multiple access (NOMA) where users have different mobility profiles. Fractional Doppler results in inter-Doppler interference (IDI) and degrades the quality of OTFS-modulated signals. We consider a downlink (DL) communication scenario where multiple users are distinguished based on their mobility profiles into a single high-mobility (HM) user and multiple low-mobility (LM) users. OTFS modulation is implemented for the HM user by embedding its information symbols in the delay-Doppler domain, while LM users' symbols are represented in the time-frequency (TF) domain. The LM users' signals are kept orthogonal to each other in the frequency domain by accessing disjoint subcarriers. Further, NOMA spectrum sharing is implemented between the HM user and the KM users to achieve higher spectral efficiency. Performance analysis in terms of DL spectral efficiency and outage probability is conducted for different system parameters. The numerical results show that IDI has a noticeable performance impact on the HM user, depending on the NOMA parameters.