This paper studies Clinical Intelligent Decision Support Systems (CIDSSs) for lung cancer segmentation, which are based on deep neural nets. A new interactive CIDSS is proposed and compared with previous approaches. Addition-ally, the purpose uncertainty problem in building interactive systems is discussed, and criteria for measuring both quality and amount of user feedback are proposed. In order to automate system evaluation, a new algorithm was used to simulate expert feedback. The proposed interactive CIDSS outperforms previous approaches (both interactive and noninteractive) on the task of lung lesion segmentation. This ap-proach looks promising both in terms of quality and expert user experience. At the same time, this paper discusses a bunch of possible modifications that can be done to improve both evaluation criteria and proposed CIDSS in future works.