Toward end-to-end mobile service provision with optimized network efficiency and quality of service, tremendous efforts have been devoted in upgrading mobile applications, transport and internet networks, and wireless communication networks for many years. However, the inherent loose coordination between different layers in the end-to-end communication networks leads to unreliable data transmission with uncontrollable packet delay and packet error rate, and a terrible waste of network resources incurred for data re-transmission. In an attempt to shed some lights on how to tackle these challenges, design methodologies and some solutions for deterministic end-to-end transmission for 6G and beyond are presented, which will bring a paradigm shift to the end-to-end wireless communication networks.