In this paper, an automatic seeded region growing algorithm is proposed for cellular image segmentation. First, the regions of interest (ROIs) extracted from the preprocessed image. Second, the initial seeds are automatically selected based on ROIs extracted from the image. Third, the most reprehensive seeds are selected using a machine learning algorithm. Finally, the cellular image is segmented into regions where each region corresponds to a seed. The aim of the proposed is to automatically extract the Region of Interests (ROI) from the cellular images in terms of overcoming the explosion, under segmentation and over segmentation problems. Experimental results show that the proposed algorithm can improve the segmented image and the segmented results are less noisy as compared to some existing algorithms.